Opis oferty:

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

In Roche´s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The Therapeutic Modalities (TMo) function is part of the Roche Pharma Research and Early Development (pRED) organization. TMo discovers and optimizes innovative drug candidates, including small molecules, biologics and nucleic acid-based therapeutics in order to deliver novel therapeutic approaches across all pRED Discovery and Translational areas (DTAs).The DELT team lies within the Lead Discovery (LD) Department in Small Molecule Research, which is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading-edge science to drive the success of Roche’s early pipeline discovery research activities through a strong expertise in high-throughput or focused screening platforms, DNA-encoded library technology (DELT), protein science & enzymology/biophysics, cell-based assays and biostructure determination. We are accountable for the provision of high-quality chemistry starting points for small-molecule projects and generating molecular and mechanistic insights that are critical for the advancement of discovery projects.

Wymagania:

• You have a Ph.D. or a Master’s degree in Biochemistry, Molecular Biology, Chemistry, or a similar field. If you have a Master’s degree, you have at least 4 years of relevant experience.
• You have proven experience in interdisciplinary project work, method development, and assay development, with a strong interest in DNA-encoded library technology (DELT) and lead discovery.
• You have a good understanding of the lead and drug discovery process and your role in that process.
• You possess excellent communication skills and are able to consistently present data and scientific information clearly to project teams. Fluency in English is expected.

Dodatki i korzyści:

• You will have an active involvement in our multidisciplinary team, which covers all aspects of DELT — from library design and synthesis through screening to hit follow-up.
• You lead and execute DNA-encoded library campaigns to identify key drug discovery starting points, including planning and running experiments, data analysis, hit selection and follow-up.
• You strategically plan and collaborate with project teams to identify novel binders for diverse targets.
• You actively collaborate with project teams to guide decision-making and drive projects forward.
• You apply computational and machine learning approaches to analyze and interpret results.
• You design experiments and present findings to diverse audiences.
• You ensure a safe and compliant working environment.